There is a mistake on version 13.13.0. I have an application on a multihomed box, the calls ingress via one IP and egress via the second IP. It does not work with version 13.13.0.
[Dec 3 18:31:56] DEBUG[188823]: rtp_engine.c:454 ast_rtp_instance_new:
Using engine ‘asterisk’ for RTP instance ‘0x7fd0080046e0’
[Dec 3 18:31:56] WARNING[188823]: res_rtp_asterisk.c:2400
create_new_socket: Unable to allocate RTP socket: Address family not supported by protocol
[Dec 3 18:31:56] WARNING[188823]: res_rtp_asterisk.c:2665 ast_rtp_new:
Failed to create a new socket for RTP instance ‘0x7fd0080046e0’
[Dec 3 18:31:56] DEBUG[188823]: rtp_engine.c:458 ast_rtp_instance_new:
Engine ‘asterisk’ failed to setup RTP instance ‘0x7fd0080046e0’
[Dec 3 18:31:56] DEBUG[188823]: rtp_engine.c:397 instance_destructor:
Destroyed RTP instance ‘0x7fd0080046e0’
[Dec 3 18:31:56] ERROR[188823]: res_pjsip_sdp_rtp.c:184 create_rtp: Unable to create RTP instance using RTP engine ‘asterisk’
[Dec 3 18:31:56] DEBUG[188823]: res_pjsip_session.c:2494
handle_outgoing_response: Method is INVITE, Response is 488 Not Acceptable Here

I repeat, if I compile version 13.12.2, ceteris paribus, the app works fine.